Biography
Dr. Tan Hong Yien serves as lecturer of Xiamen University Malaysia since 2017. She is a scientist with expertise in supporting local and international translational medicine research ie. infection disease (HIV, TB, Dengue, HepB, & HepC), immunology and public health (SARS-CoV-2). She has PhD/MSc/BSc degrees from University of Malaya. In 2013, she received her flow cytometry training at Crowe Laboratory, Burnet Institute, Melbourne, Australia.
Educational Background
2016: PhD (Immunology), University Malaya, Kuala Lumpur, Malaysia.
2008: Master of Biomedical Science, Molecular Microbiology, University Malaya, Malaysia.
2003: Bachelor of Science, Genetics and Molecular Biology (Hons.), University Malaya, Malaysia.
Projects
Current
Functional characterization of myeloid-derived suppressor cells (MDSC) and their role in the pathogenesis of severe dengue.
Past
Immune Reconstitution Disease in Severely Immuno-deficient AIDS patients commencing HAART.
A prospective observational cohort study of immune reconstitution and its consequences in immunodeficient HIV-infected patients treated with highly active anti-retroviral therapy.
HIV latent-infection of neutrophils: relation to their functional activity Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS).
Investigations on regulatory molecules in T cells of antiretroviral therapy (ART) naive and treated HIV-1 infected individuals.
Free circulating mitochondrial DNA and its association with tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS).
The potential role of mucosal associated invariant cells in Dengue.
The effect of non-alcoholic fatty liver disease and chronic hepatitis B infection on long-term outcome of liver cirrhosis.
The Role of MAIT Cell Activation in the Pathogenesis of Tuberculosis Associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS).
Selected Publications
2023
Review: Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome—An Extempore Game of Misfiring with Defense Arsenals
Ramachandran Vignesh, Pachamuthu Balakrishnan, Hong Yien Tan, Yean Kong Yong, Vijayakumar Velu, Marie Larsson and Esaki M. Shankar.
Pathogens 2023, 12, 210.
https://doi.org/10.3390/pathogens12020210
2022
Low SARS-CoV-2 viral load among vaccinated individuals infected with Delta B.1.617.2 and Omicron BA.1.1.529 but not with Omicron BA.1.1 and BA.2 variants
Sivaprakasam T. Selvavinayagam, Yean Kong Yong, Narcisse Joseph, Kannan Hemashree, Hong Yien Tan, Ying Zhang, Manivannan Rajeshkumar, Anandhazhvar Kumaresan, Raghu Kalpana, Vasudevan Kalaivani, Ayyagari Venkata Devi Monika, Suvaiyarasan Suvaithenamudhan, Meganathan Kannan, Amudhan Murugesan, Krishnasamy Narayanasamy, Sampath Palani, Marie Larsson, Esaki M. Shankar and Sivadoss Raju.
Frontiers in Public Health. 2022 SepDengue infection- Recent advances in disease pathogenesis in the era of COVID-19Dengue infection- Recent advances in disease pathogenesis in the era of COVID-19
Yean Kong Yong, Won Fen Wong, Ramachandran Vignesh, Indranil Chattopadhyay, Vijayakumar Velu, Hong Yien Tan, Ying Zhang, Marie Larsson and Esaki M. Shankar.
Frontiers in Immunology. 2022 JulcGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
Hong Yien Tan, Yean Kong Yong, Yuan Chao Xue, Huitao Liu, Tomomi Furihata, Esaki Muthu Shankar, Chen Seng Ng.
iScience. 2022 JunFactors associated with the decay of anti-SARS-CoV-2 neutralizing antibodies among recipients of an adenoviral vector-based AZD1222 and a whole-virion inactivated (BBV152) vaccine in Chennai, India: a prospective, longitudinal, cohort study
https://www.burnet.edu.au/publications/7126_high_rates_of_resumption_of… T. Selvavinayagam, Yean Kong Yong, Hong Yien Tan, Ying Zhang, Gurunathan Subramanian, Manivannan Rajeshkumar, Kalaivani Vasudevan, Priyanka Jayapal, Krishnasamy Narayanasamy, Dinesh Ramesh, Sampath Palani, Marie Larsson, Esaki M. Shankar, and Sivadoss Raju.
Frontiers in Medicine. 2022 Jun
2021
Mucosal-associated invariant T Cells: Diplomatic front-runners in the fight against Hepatitis B virus infection
https://www.burnet.edu.au/publications/7126_high_rates_of_resumption_of… Yien Tan, Yean Kong Yong, Chen Seng Ng, Jaisheela Vimali, Rosmawati Mohamed, Amudhan Murugesan, Vijayakumar Velu, Marie Larsson, Esaki Muthu Shankar.
Critical Reviews™ in Immunology.2021 JanChronic inflammation involves CCL11 and IL-13 to facilitate the development of liver cirrhosis and fibrosis in chronic hepatitis B virus infection
Sui Weng Wong, Yi Wen Ting, Yean Kong Yong, Hong Yien Tan, Muttiah Barathan, Behnaz Riazalhosseini, Chook Jack Bee, Kok Keng Tee, Marie Larsson, Vijayakumar Velu, Esaki M. Shankar, Rosmawati Mohamed.
Scandinavian Journal of Clinical and Laboratory Investigation. 2021 JanPeripheral follicular T helper cells and MAIT cells represent activated phenotypes during the febrile phase of acute dengue virus infection
Sathappan U Preeyaa, Amudhan Murugesan, Surliappan Sopnajothi, Yean Kong Yong, Hong Yien Tan, Marie Larsson, Vijayakumar Velu, Esaki M Shankar.
Viral Immunology. 2021 Jan
2020
Brief report: Diminished coinhibitory molecule 2B4 expression is associated with preserved iNKT cell phenotype in HIV long-term nonprogressors
https://www.burnet.edu.au/publications/7126_high_rates_of_resumption_of… W Ansari, Fareed Ahmad, Esaki M Shankar, Yean Kong Yong, Hong Yien Tan, Roland Jacobs 4, Marie Larsson, Vijayakumar Velu, Adeeba Kamarulzaman, Reinhold E Schmidt.
Journal of Acquired Immune Deficiency Syndromes. 2020 May
2019
Immune biomarkers for the diagnosis and treatment monitoring of tuberculosis: Current developments and future prospects
Yean Kong Yong, Hong Yien Tan, Alireza Saeidi, Won F. Wong, Ramachandran Vignesh, Vijayakumar Velu, Rajaraman Eri, Marie Larsson, Esaki M. Shankar.
Frontiers in Microbiology. 2019 Dec
2018
Hyper-expression of PD-1 is associated with the levels of exhausted and dysfunctional phenotypes of circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T (MAIT) cells in chronic hepatitis B virus infection
Yean Kong Yong, Alireza Saeidi, Hong Yien Tan, Mohamed Rosmawati, Philip F Enström, Rami Al Batran, V Vasuki, Indranil Chattopadhyay, Amudhan Murugesan, Ramachandran Vignesh, Adeeba Kamarulzaman, Jayakumar Rajarajeswaran, Abdul W Ansari, Jamuna Vadivelu, James E Ussher, Vijayakumar Velu, Marie Larsson, Esaki M Shankar.
Frontiers in Immunology. 2018 Mar
2017
Role of cytokines in the assessment of clinical outcome and neuroimaging findings in patients with tuberculous meningitis
Mei-Ling Sharon Tai, Hong Yien Tan, Yean Kong Yong, Esaki M Shankar, Shanthi Viswanathan, Hazman Mohd Nor, Kartini Rahmat , Jun-Fai Yap, Boon-Seng Ng, Chong Tin Tan.
Neurology Asia. 2017 OctDecrease of CD69 levels on TCR Vα7.2+CD4+ innate-like lymphocytes is associated with impaired cytotoxic functions in chronic hepatitis B virus-infected patients
Yean Kong Yong, Hong Yien Tan, Alireza Saeidi, Mohamed Rosmawati, Nadia Atiya, Abdul W Ansari, Jayakumar Rajarajeswaran, Jamuna Vadivelu, Vijayakumar Velu, Marie Larsson, Esaki M Shankar.
Innate Immunity. 2017 JulAberrant monocyte responses predict and characterize dengue virus infection in individuals with severe disease
Yean Kong Yong, Hong Yien Tan, Soe Hui Jen, Esaki M. Shankar, Santha K. Natkunam, Jameela Sathar, Rishya Manikam, and Shamala D. Sekaran.
Journal of Translational Medicine. 2017 Jul
Checkpoint regulatory molecule 2B4 (CD244) upregulation is associated with invariant natural killer T cell alterations and human immunodeficiency virus disease progression
Fareed Ahmad, Esaki M Shankar, Yean Kong Yong, Hong Yien Tan, Gerrit Ahrenstorf, Roland Jacobs, Marie Larsson, Reinhold E Schmidt, Adeeba Kamarulzaman, Abdul W Ansari.
Frontiers in Immunology. 2017 Mar
2016
Functional role of mucosal-associated invariant T cells in HIV infection
Alireza Saeidi, Rada Ellegård, Yean Kong Yong, Hong Yien Tan, Vijayakumar Velu, James E Ussher, Marie Larsson, Esaki M Shankar.
Journal of Leukocyte Biology. 2016 AugAberrant inflammasome activation characterizes Tuberculosis-associated immune reconstitution inflammatory syndrome
Hong Yien Tan, Yean Kong Yong, Esaki M Shankar, Geza Paukovics, Rada Ellegård, Marie Larsson, Adeeba Kamarulzaman, Martyn A French, Suzanne M Crowe.
Journal of Immunology. 2016 May
2015
Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8+ T cells in HIV/TB co-infection
Alireza Saeidi, Yee K Chong, Yean Kong Yong, Hong Yien Tan, Muttiah Barathan, Jayakumar Rajarajeswaran, Negar S Sabet, Shamala D Sekaran, Sasheela Ponnampalavanar, Karlhans F Che, Vijayakumar Velu 8, Adeeba Kamarulzaman, Marie Larsson, Esaki M Shankar.
Cellular Immunology. 2015 SepAttrition of TCR Vα7.2+ CD161++ MAIT cells in HIV-Tuberculosis co-infection Is associated with elevated levels of PD-1 expression
Alireza Saeidi, Vicky L Tien Tien, Rami Al-Batran, Haider A Al-Darraji, Hong Yien Tan, Yean Kong Yong, Sasheela Ponnampalavanar, Muttiah Barathan, Devi V Rukumani, Abdul W Ansari, Vijayakumar Velu, Adeeba Kamarulzaman, Marie Larsson, Esaki M Shankar.
PLoS One. 2015 AprPlasma interleukin-18 levels are a biomarker of innate immune responses that predict and characterize Tuberculosis-associated immune reconstitution inflammatory syndrom
Hong Yien Tan, Yean Kong Yong, Bruno B Andrade, Esaki M Shankar, Sasheela Ponnampalavanar, Sharifah F S Omar, Gopalan Narendran, Adeeba Kamarulzaman, Soumya Swaminathan, Irini Sereti, Suzanne M Crowe, Martyn A French.
AIDS. 2015 Feb
Grants
XMURF
Functional Characterization of Myeloid-Derived Suppressor Cells (MDSC) and Their Role in the Pathogenesis of Severe Dengue. Xiamen University Malaysia (XMUM) Research Fund. RM60,000. XMUMRF/2020-C5/ITCM/0003. 2020-ongoing. Principle Investigator.