Biography
Dr. Tan Chu Shan (PhD, ChM) is an Assistant Professor at Xiamen University Malaysia with multidisciplinary expertise spanning pharmacology, analytical chemistry, laboratory medicine, and healthcare research. She earned her PhD in Pharmacology from Universiti Sains Malaysia, where she investigated antihypertensive herbal formulations, vascular pharmacology, and mechanisms of vasodilation in natural products. Her doctoral and postdoctoral work contributed to numerous peer-reviewed publications, international awards, and collaborative research projects.
Before returning to academia, Dr. Tan accumulated substantial industrial experience in scientific instrumentation and analytical sciences. She served as Application and Product Specialist and have many years experience in supporting advanced analytical platforms. These experiences strengthened her expertise in laboratory workflow optimization, method development, quality assurance, and translational research applications.
Her research interests mainly focus on natural products and traditional medicine, cardiovascular pharmacology, metabolomics, analytical method development, pharmaceutical quality evaluation, and AI-assisted healthcare analytics. She is particularly interested in integrating advanced analytical technologies with biostatistical approaches to advance precision medicine, and enhance pharmaceutical quality assessment. With experience spanning both academia and industry, she has authored more than 30 scientific publications and actively promotes industry-academia collaboration while mentoring the next generation of scientists in biomedical and pharmaceutical sciences.
ORCID ID: 0000-0002-9176-9661
SCOPUS ID: 5718-9310-0591
Researcher ID: S-8560-2019
Research Interest
Natural Products and Herbal Medicine Research
• Pharmacological evaluation of medicinal plants
• Traditional Chinese Medicine (TCM) standardization
• Bioactive compound identification
• Evidence-based herbal medicine developmentCardiovascular and Vascular Pharmacology
• Hypertension and cardiovascular diseases
• Vasodilation and endothelial function
• Mechanistic pharmacology of natural compounds
• Translational cardiovascular researchAnalytical and Pharmaceutical Sciences
• Chromatographic and spectroscopic method development
• Pharmaceutical quality control and quality assurance
• Fingerprinting and characterization of herbal products
• Regulatory science and product authentication
Educational Background
PhD (Major in Pharmacology), School of Pharmaceutical Sciences, Universiti Sains Malaysia, (graduation year 2018)
BSc (Industry Biotechnology), Universiti Malaysia Pahang (2014)
Research Experience / Grants
Malaysia Toray Science Foundation, Science and Technology Grant Award (2015)
Representative Publications
YEAR 2026
CH Ng., ZX Chim., CS Tan., WY Tew., Q Qiu., I Kusumawat., Y Chen., S Wu., and MF Yam. (2026). Integration of an iterative factor into a validated HPTLC method for quantification of koumine in the toxic plant Gelsemium elegans Benth. Front. Pharmacol. 17:1779290. doi: 10.3389/fphar.2026.1779290. IF: 5.4
YEAR 2025
MF Yam., WY Tew., CS Tan., HW Loh., Q Qiu., CS Yan., X Xu., L Ouyang., R Zhou., YP Yap., W Xu., W Xu., LK Teh. (2025). Mechanistic insights into the synergistic vasodilatory actions of eupatorin, sinensetin, and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in ex vivo aortic ring model and their antihypertensive efficacy in in vivo rat model. Hypertens Res., 48(11):2897-2910. doi: 10.1038/s41440-025-02298-6. IF:5.0
YEAR 2024
MF Yam, WY Tew, CS Tan, Q Qiu, R Zhou, X Wang, YP Yap, W Xu, W Xu. (2024). Investigation of synergistic interaction of sinensetin, eupatorin, and 3′-hydroxy-5, 6, 7, 4′-tetramethoxyflavone in vasodilation efficacy. Hypertension Research, 47 (11), 3193-3199. IF:5.0
WY Tew, CS Tan, CS Yan, HW Loh, X Wang, X Wen, X Wei, MF Yam. (2024). Mechanistic study on vasodilatory and antihypertensive effects of hesperetin: ex vivo and in vivo approaches . Hypertension Research, 47 (9), 2416-2434. IF:5.0
YEAR 2023
Tew, WY. Tan CS, Chong SY, Loh HW, Xu W, Xu W, Yam MF. (2023). Evaluation of vasodilatory effect and antihypertensive effect of chrysin through in vitro and sub-chronic in vivo study. Biomedicine & Pharmacolotherapy., 157 , 114020. IF:7.5
YEAR 2022
Application note: Rapid Chinese Medicine Authetification using TCM Materia Medica Digital Library . Perkin Elmer.
Yoon, TL., Yeap, ZQ., Tan, CS., Chen, Y., Chen, J., Yam, MF. (2022). A novel machine learning scheme for classification of medicinal herbs based on 2D-FTIR fingerprints. Spectrochim Acta A Mol Biomol Spectrosc., 266:120440. doi: 10.1016/j.saa.2021.120440. Epub 2021 Sep 27.
YEAR 2021
Tan, C.S., Leow, S.Y. Chen, Y., Tan, CJ., Yoon, T.I., Yam, M. F. (2021). Comparison of FTIR Spectrum with the chemometric and machine learning classifying analysis for differentiating guan mutong a nephrotoxic and carcinogenic traditional chinese medicine with Chuan Murong. Microchemical Journal, 163. IF: 5.2
Tan, CS, Tew, WY., Chen, J., Yam, MF. Vasorelaxant effect of 5,7,4'- Trihydroxyflavanone (Naringenin) via endothelium dependent, potassium and calcium channels in Sprague Dawley rats:Aortic ring model . Chemico-Biological Interactions, 348: 109620 . DOI: 10.1016/j.cbi.2021.109620. IF: 5.2
Chen, Y., Tan, C.S., Ng, C.H., Yam, M.F., Wu, S., Sun. Z. Development of a HPTLC method with interative calibration approach for quantitative evaluation of kinsenoside content in different type of Anoectochilus roxburghii. Microchemical Journal, 165. IF: 5.2
N Mohtar, T Parumasivam, AM Gazzali, CS Tan, ML Tan, R Othman, SS Fazalul Rahiman, H A Wahab. (2021). Advanced Nanoparticle-Based Drug Delivery Systems and Their Cellular Evaluation for Non-Small Cell Lung Cancer Treatment. Cancers , 13 (14), 3539. IF: 4.8.
YEAR 2020
Tan, C.S., Loh, Y.C., Tew, W.Y., Yam, M.F. (2020). Vasorelaxant effect of 3,5,4’-trihydroxytrans-stilbene (resveratrol) and its underlying mechanism. Inflammopharmacology， 1-9. IF: 5.3
Tew, W.Y., Tan, C.S., Asmawi, M.Z., Yam, M.F. (2020). Vasorelaxant effect of 3,5,4’-trihydroxytrans-stilbene (resveratrol) and its underlying mechanism. European Journal of Pharmacology. IF: 5.7
Lok, B., Sandai, D., Baharetha, H, M., Nazari V, M., Asif, M., Tan, C.S., Abdul Majid, A.M.S. (2020). Anticancer effect of Psidium guajava (Guava) leaf extracts against colorectal cancer through inhibition of angiogenesis. Asian Pacific Journal of Tropical Biomedicine, 10(7): 293-307.
YEAR 2019
Tan, C.S., Loh, Y.C., Ch’ng, Y.S., Ng, C.H., Yeap, Z.Q., Mariam Ahmad., Mohd. Z.A., Yam, M.F. (2019). Vasorelaxant and chemical fingerprint studies of Citrus reticulatae pericarpium extracts. Journal of Ethnopharmacology, 2019, 232, 135-144. IF: 3.414
Tan, C.S., Ng, C.H., Loh, Y.C., Yam, M.F. (2019) A traditional folk medicine in Malaysia: Porcupine bezoar. Oriental Pharmacy and Experimental Medicine.
Loh, Y.C., Tan, C.S., Ch'ng, Y.S., Ng, C.H., Yeap, Z.Q., Yam, M.F. (2019). Mechanisms of action of Panax notoginseng ethanolic extract for its vasodilatory effects and partial characterization of vasoactive compounds. Hypertension Research, 42. doi: 10.1038/s41440- 018-0139-9. IF: 3.581
Ng, C.H., Tan, C.S., Yeap, Z.Q., Yam, M.F. (2019). HPTLC-UV fingerprints of Gelsemium elegans and koumine contents determined by densitometry compared to UPLC-MS/MS. CAMAG Bibliography Service (CBS), 122, 5-7.
陈楚珊(Tan CS.), 吴秋虹(Ng CH), 罗元骏 (Loh YC), 任文辉(Yam MF). (2019).马来西亚民 间神奇传统草药：箭猪枣。第一届全国中医优势病症临床研究交流大会暨新时代千名中医药名家论道西湖，page 367
YEAR 2018
Tan, C.S., Loh, Y.C., Ng, C.H., Ch’ng, Y.S., Mohd. Z.A., Mariam Ahmad., Yam, M.F. (2018). Anti-hypertensive and vasodilatory effects of amended Banxia Baizhu Tianma Tang. Biomedicine & Pharmacotherapy, 97, 985–994. IF: 7.5
Tan, C.S., Yam, M.F. (2018). Mechanism of vasorelaxation induced by 3′-hydroxy-5,6,7,4′-tetramethoxyflavone in the rats aortic ring assay. Naunyn-Schmiedeberg's Archives of Pharmacology, 391(6), 561-569. IF: 4.0
Yam, M.F., Tan, C.S.*, Ruan, S. (2018). Vasorelaxant effect of sinensetin via NO/sGC/cGMP pathway, potassium, and calcium channels. Hypertension Research. doi: 10.1038/s41440-018-0083-8. IF:5.0
Loh, Y.C., Tan, C.S., Ch'ng, Y.S., Yeap, Z.Q., Ng, C.H., Yam, M.F. (2018). Overview of the microenvironment of vasculature in vascular tone regulation. International Journal of Molecular Sciences, 19, 120. IF: 5.6
Loh, Y.C., Tan, C. S., Wan Maznah, W. O. (2018). Alternative approach in pharmacological research. SF Journal of Pharmaceutical and Analytical Chemistry, 1(1), 1006.
Ch’ng, Y.S., Loh, Y.C., Tan C.S., Mariam Ahmad., Mohd. Z.A., Wan Mazna, W.O., Yam, M.F. (2018). Vasodilation and antihypertensive activities of Swietenia macrophylla (Mahogany) seed extract. J Med Food, 21 (3), 289-301. IF: 1.80
Yam, M.F., Loh, Y.C., Tan, C.S., Siti Khadijah, A., Nizar Abdul, M., and Rusliza, B. General pathways of pain sensation and the major neurotransmitters involved in pain regulation. International Journal of Molecular Sciences, 19, 2164. IF: 5.6
Ng, C.H., Chen, Y., Ch’ng Y.S., Tan, C.S., Yeap, Z.Q., Loh, Y.C., Wu, S., Yam, M.F. Application of mid-infared spectroscopy with multivariate analysis for the discrimination of toxic plant, Gelsemium elegans. Vibrational Spectroscopy, In press. IF:3.1
Tan, C.S., Yam, M.F. Vasorelaxant study of standardized extract of Pericarpium Citrus reticulatae. Frontiers in Pharmacology. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.0006
YEAR 2017
Tan, C.S., Ch’ng, Y.S., Loh, Y.C., Mohd. Z.A., Mariam Ahmad., Yam, M.F. (2017). Vasorelaxation effect of Glycyrrhizae uralensis through the endothelium-dependent pathway. J. Ethnopharmacol.,199, 149-160. IF: 5.4
Tan, C.S., Loh, Y.C., Ch’ng, Y.S., Mariam Ahmad, Mohd, Z.A., Yam, M.F. (2017). Decomposition and Reformulation of Banxia Baizhu Tianma Decoction: A Vasodilatory Approach. Chinese Herbal Medicines, 9(2), 134-146. IF: 11.2
Loh, Y.C., Tan, C.S., Ch’ng, Y.S., Mariam Ahmad, Mohd. Zaini Asmawi, and Yam, M.F. (2017). Vasodilatory Effects of Combined Traditional Chinese Medicinal Herbs in Optimized Ratio. J Med Food, 20(3), 265–278. IF: 1.8
Loh, Y.C., Tan, C.S., Ch’ng, Y.S., Mariam Ahmad, Ng, C.H., Mohd. Zaini Asmawi, and Yam, M.F. (2017). Overview of signaling mechanism pathways employed by BPAid in vasodilatory activity. J Med Food, 20(12). IF: 1.8
Ch’ng, Y.S., Loh, Y.C., Tan, C.S., Mariam Ahmad, Mohd. Zaini Asmawi, Wan Maznah Wan Omar, and Yam, M.F. (2017). Vasorelaxant properties of Vernonia amygdalina ethanol extract and its possible mechanism. Pharmaceutical Biology, 55, 2083-2094. IF:2.492
Loh, Y.C., Ch’ng, Y.S., Tan, C.S., Mariam Ahmad, Mohd. Zaini Asmawi, and Yam, M.F. (2017). Mechanism actions of Uncaria rhynchophylla ethanolic extract for Its vasodilatory effects. J Med Food, 20(9). IF: 1.8
YEAR 2016
Yam, M.F., Tan, C.S.*, Mariam Ahmad, Ruan, S. (2016). Mechanism of vasorelaxation induced by eupatorin in the rats aortic ring. Eur. J. Pharmacol., 789, 27-36. IF: 5.7
Yam, M.F., Tan, C.S.*, Ahmad, M., Ruan, S. (2016). Vasorelaxant action of the chloroform fraction of Orthosiphon stamineus via NO/cGMP pathway, potassium and calcium channels. Am. J. Chin. Med., 44(7), 1413–1439. IF: 7.8
Loh, Y.C., Tan, C.S., Ch’ng, Y.S., Ahmad, M., Mohd, Z.A, Yam, M.F. (2016). Overview of antagonists used for determining the mechanisms of action employed by potential vasodilators with their suggested signaling pathways. Molecules, 21(4), 495. IF: 5.1
Ch’ng, Y.S., Tan, C.S., Loh, Y.C., Mariam Ahmad, Mohd. Z.A., Yam, M.F. (2016). Vasorelaxation study and tri-step infrared spectroscopy analysis of Malaysian local herbs. J Pharmacopuncture. 19(2), 145-154. IF:1.5
YEAR 2014
Tan, C.S., Makky, E. A., Eman, N. A., & Manaf, A. M. (2014). The use of Moringa oleifera seed as a natural coagulant for wastewater treatment and heavy metals removal. Jokull Journal, 64(8),188-200. IF: 1.25
Eman, N.A., Tan, C.S., & Makky, E. A. (2014). Impact of Moringa oleifera Cake Residue Application on Waste Water Treatment: A Case Study. Journal of Water Resource and Protection, 6, 677-687.
Honors / Awards
- International Conference and Exposition on Inventions by Institutions of Higher Learning (Pecipta), Gold Medal. (2019)
- Malaysia Technology Expo (MTE), Silver Medal. (2019)
- International Invention, Innovation & Technology Exhibition, Malaysia (ITEX 2018), Silver Medal. (2018)
- Hadiah Sanjungan, for Journal Publication Award, USM. (October 2018)
Title: Vasorelaxation effect of Glycyrrhizae uralensis through the endothelium-dependent pathway. Journal of Ethnopharmacology - Hadiah Sanggar Sanjung (Journal Publication), USM, October 2018.
Title: Vasodilatory effects of combined traditional chinese medicinal herbs in optimized ratio. Journal of Medicinal Food - Hadiah Sanggar Sanjung (Journal Publication), USM, October 2018.
Title: Overview of signaling mechanism pathways employed by BPAid in vasodilatory activity. Journal of Medicinal Food - Hadiah Sanggar Sanjung (Journal Publication), USM, , October 2018.
Title: Vasorelaxant properties of Vernonia amygdalina ethanol extract and its possible mechanism. Pharmaceutical Biology. - Hadiah Sanggar Sanjung (Journal Publication), USM, October 2018.
Title: Mechanism actions of Uncaria rhynchophylla ethanolic extract for Its vasodilatory effects. Journal of Medicinal Food - Sanggar Sanjung, for Journal Publication Award, USM. (2016)
- Majlis Persada Kencana 2017, Publication Award. (2016)
Professional Memberships & Certifications
- Active member of Malaysia Society of Pharmacology and Physiology (MSPP).
No. of member: MSPP/M/0042/2018 - HRD Corp Accredited Trainer | Trainer ID: 25142
- IKM Registered Chemist : L/2716/8049/18
- Certified Digital Marketing Specialist